Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells

Micronuclei as A Biomarker in Monitoring Genetic Damage in Down Syndrome

Background: Down syndrome (DS) is a most common cause of mental retardation in humans. Monitoring genetic damage in DS individuals helps in evaluating genetic damage. Micronucleus assay is potentially an excellent tool to serve as a biomarker which detects chromosomal loss or malfunction. Aim of the study: The objective of the study is to evaluate micronuclei (MN) frequency in exfoliated buccal...

Black Cohosh

Muscle damage induced by black cohosh (Cimicifuga racemosa).

Extracts of black cohosh (Cimicifuga racemosa) are commonly used for the treatment of symptoms associated with menopause. Adverse events with black cohosh are rare, mild and reversible. A few number of serious adverse events, including hepatic and circulatory conditions, have been also reported, but without a clear causality relationship. We report the case of a woman with severe asthenia and v...

phylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran

in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...

Benzene metabolite, 1,2,4-benzenetriol, induces micronuclei and oxidative DNA damage in human lymphocytes and HL60 cells.

The triphenolic metabolite of benzene, 1,2,4-benzenetriol (BT), is readily oxidized to its corresponding quinone via a semiquinone radical. During this process, active oxygen species are formed that may damage DNA and other cellular macromolecules. The ability of BT to induce micronuclei (MN) and oxidative DNA damage has been investigated in both human lymphocytes and HL60 cells. An antikinetoc...